Team

Staff Profiles

Zizhen Yao, Ph.D.

Scientist II

Zizhen Yao joined the Allen Institute for Brain Science in 2014 as part of a large interdisciplinary effort to categorize the diversity of neural cell types and the molecular mechanisms leading to cell type specificity. Prior to joining the Allen Institute for Brain Science, she worked at Fred Hutchinson Cancer Research Center developing computational techniques for analyzing high throughput epigenetic and transcriptomic data to study myogenesis and neurogenesis during normal development and in disease.

Zizhen Yao received a Ph.D. in computer science from University of Washington in Seattle, where she studied in silico genome screening of functional noncoding RNAs.

Research

Research Interests

I am interested in genetic and epigenetic regulation of transcription factors for cell fate determination during brain development in comparison to development in other systems to understand general principles of cell differentiation.

Expertise

  • Informatics

Research Programs

  • MAT
  • in vitro Human Cell Types
  • Mouse Cell Types

Selected Publications View on PUBMED

A Suite of Transgenic Driver and Reporter Mouse Lines with Enhanced Brain-Cell-Type Targeting and Functionality

Cell
July 12, 2018

Daigle TL, Madisen L, Hage TA, Valley MT, Knoblich U, Larsen RS, Takeno MM, Huang L, Gu H, Larsen R, Mills M, Bosma-Moody A, Siverts LA, Walker M, Graybuck LT, Yao Z, Fong O, Nguyen TN, Garren E, Lenz GH, Chavarha M, Pendergraft J, Harrington J, Hirokawa KE, Harris JA, Nicovich PR, McGraw MJ, Ollerenshaw DR, Smith KA, Baker CA, Ting JT, Sunkin SM, Lecoq J, Lin MZ2, Boyden ES, Murphy GJ, da Costa NM, Waters J, Li L, Tasic B, Zeng H

DUX4-induced gene expression is the major molecular signature in FSHD skeletal muscle

Human Molecular Genetics
October 15, 2014

Yao Z, Snider L, Balog J, Lemmers RJ, Van Der Maarel SM, Tawil R, Tapscott SJ

Comparison of endogenous and overexpressed MyoD shows enhanced binding of physiologically bound sites

Skeletal Muscle
April 8, 2013

Yao Z, Fong AP, Cao Y, Ruzzo WL, Gentleman RC, Tapscott SJ

Comparison of genome-wide binding of MyoD in normal human myogenic cells and rhabdomyosarcomas identifies regional and local suppression of promyogenic transcription factors

Molecular and Cellular Biology
February 2013

MacQuarrie KL, Yao Z, Fong AP, Diede SJ, Rudzinski ER, Hawkins DS, Tapscott SJ

Genetic and epigenetic determinants of neurogenesis and myogenesis

Developmental Cell
April 17, 2012

Fong AP, Yao Z, Zhong JW, Cao Y, Ruzzo WL, Gentleman RC, Tapscott SJ

DUX4 activates germline genes, retroelements, and immune mediators: implications for facioscapulohumeral dystrophy

Developmental Cell
January 17, 2012

Geng LN, Yao Z, Snider L, Fong AP, Cech JN, Young JM, van der Maarel SM, Ruzzo WL, Gentleman RC, Tawil R, Tapscott SJ