Team

Staff Profiles

Tim Jarsky, Ph.D.

Senior Manager, Electrophysiology

Tim Jarsky joined the Allen Institute for Brain Science in 2013 as part of the Mouse Cell Types research program. Tim is part of a team of scientists working to map and characterize microcircuits in the mouse visual cortex.  Prior to joining the institute, he investigated the contribution of synaptic processing to visual computations in the retina. As a doctoral student he studied the role of intrinsic membrane properties in hippocampal information processing. His early research experiences include respiratory physiology, circadian rhythms, endocrine physiology, and avian flight physiology. Tim obtained his PhD in neuroscience from Northwestern University, MS in zoology and BS in biology from the University of Toronto.

Research

Research Interests

Research Interests The Allen Institute for Brain Science is in the early stages of a large-scale, multi-year, experimental and theoretical effort to study coding in the cerebral cortex. A critical component of this effort is to systematically characterize neuronal cell types in the cortex and its afferent and efferent structures at molecular, anatomical, and physiological levels. One goal for the physiological study of neuronal cell types is to investigate synaptic connections formed by cell types, with in vitro preparations, using electrical and optical activation combined with multiple simultaneous neuronal recordings. Using this approach, we will address the following questions: Do different subpopulations of cells, defined by genetic markers, form discrete microcircuits? How do connectivity and the synaptic properties of the circuit influence circuit computations? Do the microcircuit properties correlate with functional properties?

Expertise

  • Synaptic physiology
  • Intrinsic physiology
  • Electrophysiology
  • Calcium imaging

Selected Publications

Sparse recurrent excitatory connectivity in the microcircuit of the adult mouse and human cortex

eLife
September 26, 2018

Seeman SC, Campagnola L, Davoudian PA, Hoggarth A, Hage TA, Bosma-Moody A, Baker CA, Lee, JH, Mihalas S, Teeter C, Ko AL, Ojemann JG, Gwinn RP, Silbergeld DL, Cobbs C, Phillips J, Lein E, Murphy G, Koch C, Zeng H, Jarsky T

Classification of electrophysiological and morphological types in mouse visual cortex

bioRxiv
July 17, 2018

Gouwens NW, Sorensen SA, Berg J, Lee C, Jarsky T, Ting J, Sunkin S, Feng D, Anastassiou C, Barkan E, Bickley K, Blesie N, Braun T, Brouner K, Budzillo A, Caldejon S, Casper T, Castelli D, Chong P, Crichton K, Cuhaciyan C, Daigle T, Dalley R, Dee N, Desta T, Dingman S, Doperalski A, Dotson N, Egdorf T, Fisher M, de Frates RA, Garren E, Garwood M, Gary A, Gaudreault N, Godfrey K, Gorham M, Gu H, Habel C, Hadley K, Harrington J, Harris J, Henry A, Hill D, Josephsen S, Kebede S, Kim L, Kroll M, Lee B, Lemon T, Liu X, Long B, Mann R, McGraw M, Mihalas S, Mukora A, Murphy GJ, Ng L, Ngo K, Nguyen TN, Nicovich PR, Oldre A, Park D, Parry S, Perkins J, Potekhina L, Reid D, Robertson M, Sandman D, Schroedter M, Slaughterbeck C, Soler-Llavina C, Sulc J, Szafer A, Tasic B, Taskin N, Teeter C, Thatra N, Tung H, Wakeman W, Williams G, Young R, Zhou Z, Farrell C, Peng H, Hawrylycz MJ, Lein E, Ng L, Arkhipov A, Bernard A, Phillips J, Zeng H, Koch C

Visual physiology of the Layer 4 cortical circuit in silico

PLoS Computational Biology
November 12, 2018

Arkhipov A, Gouwens NW, Billeh YN, Gratiy S, Iyer R, Wei Z, Xu Z, Berg J, Buice M, Cain N, da Costa N, de Vries S, Denman D, Durand S, Feng D, Jarsky T, Lecoq J, Lee B, Li L, Mihalas S, Ocker GK, Olsen SR, Reid RC, Soler-LLavina G, Sorensen SA, Wang Q, Waters J, Scanziani M, Koch C