Our bodies are made up of many different kinds of cells, each with a set of fundamental tasks, such as manufacturing proteins and producing energy.
These cells also engage in specialized activities, such as beating in coordination to pump blood through the heart, forming a barrier to protect the stomach from its own acid, or migrating in a directed way to fend off infection.
While we know what most cells do and are beginning to know what specific genes are expressed in different cell types, we do not know how expressed genes and a cell’s environment (the influence of neighboring cells, connective tissue, infection, etc.) combine to generate different cellular behaviors. We also do not fully understand how DNA alterations can perturb normal cellular behaviors to cause many diseases.
Our goal is to collect comprehensive dynamic image data on cellular behavior in a way that enables us to create computational models of how cells perform their roles.
Allen Cell Collection
The Allen Institute for Cell Science has released the Allen Cell Collection: the first publicly available collection of gene edited, fluorescently tagged human induced pluripotent stem cells that target key cellular structures with unprecedented clarity.
Gene list and status
Updated November 2016